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KMID : 0603820100160040239
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Journal of Experimental & Biomedical Science
2010 Volume.16 No. 4 p.239 ~ p.246
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Liver PPARα and UCP2 are Involved in the Regulation of Ovariectomy-Induced Adiposity and Steatosis by Swim Training
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Jeong Sun-Hyo
Yoon Mi-Chung
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Abstract
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It is suggested that ovariectomy induces body weight gain primarily in the form of adipose tissue in rodents. Since liver peroxisome proliferator-activated receptor α (PPARα) and uncoupling 2 (UCP2) are involved in the regulation of energy expenditure, it was investigated whether swim training regulates ovariectomy-induced adiposity and steatosis through liver PPARα and UCP2 activation in female ovariectomized mice, an animal model of postmenopausal women. Swim-trained mice had significantly decreased adipose tissue weights compared with sedentary control mice. Histological analysis showed that hepatic lipid accumulation was inhibited by swim training. Concomitantly, swim training significantly increased mRNA levels of PPARα and its target genes responsible for peroxisomal fatty acid β-oxidation, such as acyl-CoA oxidase, enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase and thiolase in the liver. Moreover, swim training induced the mRNA expression of UCP2. These results suggest that swim training can effectively prevent adiposity and steatosis caused by ovariectomy, in part through activation of liver PPARα and UCP2 in female obese mice.
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KEYWORD
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Ovariectomy, Adiposity, Steatosis, Liver, Swim training, PPARα, UCP2
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